Assembly of the Vasculature and Its Regulation by Peter Carmeliet (auth.), Robert J. Tomanek (eds.)

By Peter Carmeliet (auth.), Robert J. Tomanek (eds.)

The total scope of this new sequence should be to adapt an figuring out of the genetic foundation of (1) how early mesoderm commits to cells of a middle lineage that gradually and irreversibly gather right into a segmented, basic middle tube that may be transformed right into a four-chambered organ, and (2) how blood vessels are derived and assembled either within the middle and within the physique. Our relevant goal is to set up a 4-dimensional, spatiotemporal origin for the guts and blood vessels that may be genetically dissected for functionality and mechanism. for the reason that Robert DeHaan's seminal bankruptcy "Morphogenesis of the Vertebrate middle" released in Organogenesis (Holt Rinehart & Winston, long island) in 1965, there were strangely few books dedicated to the topic of cardiovascular mor­ phogenesis, regardless of the big development of curiosity that happened nationally and the world over. such a lot writings at the topic were scholarly compilations of the court cases of significant nationwide or overseas symposia or multiauthored volumes, frequently and not using a particular subject. what's lacking are the unifying recommendations that may make experience out of a burgeoning database of evidence. The Editorial Board of this new sequence believes the time has come for a booklet sequence devoted to aerobic­ vascular morphogenesis that might serve not just as a big archival and didac­ tic reference resource if you happen to have lately come into the sector but additionally as a advisor to the evolution of afield that's in actual fact coming of age.

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Development 125:4565-4574. 118. A. (1998). Renin-expressing cells are associated with branching of the developing kidney vasculature. J Am Soc Nephrol 9:63-71. 119. C, Mikawa, T. (1998). Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers. Proc Nat! Acad Sci USA 95:6815-6818. 120. , Weitzer, G. (1997). Desmin in muscle formation and maintenance: knockouts and consequences. Cell Struct Funct 22:103-116. 121. , et al. (1997). Targetting of the gene encoding fibrillin-l recapitulates the vascular aspect of Marfan syndrome.

1998). Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers. Proc Nat! Acad Sci USA 95:6815-6818. 120. , Weitzer, G. (1997). Desmin in muscle formation and maintenance: knockouts and consequences. Cell Struct Funct 22:103-116. 121. , et al. (1997). Targetting of the gene encoding fibrillin-l recapitulates the vascular aspect of Marfan syndrome. Nat Genet 17: 218-222. 122. C, et al. (1998). Elastin is an essential determinant of arterial morphogenesis.

115. , et al. (1994). Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet 8:345-351. 116. , et al. (1996). Role of tissue factor in embryonic blood vessel development. Nature 383:73-75. 117. , et al. (1998). Requirement of the MADS-box transcription factor MEF2C for vascular development. Development 125:4565-4574. 118. A. (1998). Renin-expressing cells are associated with branching of the developing kidney vasculature.

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