Biomedical Aspects of Botulism by George E. Lewis Jr.

By George E. Lewis Jr.

Show description

Read Online or Download Biomedical Aspects of Botulism PDF

Best botany books

Handbook to the Construction and Use of Insect Collection and Rearing Devices: A guide for teachers with suggested classroom applications

Bugs are nice school room learn organisms. they're effortless to assemble and lift and feature a desirable array of existence histories. simply because they're small and feature large reproductive capability ecological experiences of dispersion, predation, parasitism and replica could be studied in compressed timeframes and small parts relative to comparable reports of bigger organisms.

Additional resources for Biomedical Aspects of Botulism

Sample text

It was also found that iron or manganese ion inhibits the binding between Μ toxin and the second non­ toxic protein (20). The molecular dissociation of the progenitor toxin is re­ versible. 0, molecular reassociation occurs forming molecules indistinguishable from the parental progenitor toxin. 2. 0, it forms a single boundary at the 10S position. 0 (41). 2 or higher. Type Ε progenitor toxin extracted from young cultured bacterial cells is a complex with RNA of various molecular sizes. The RNA molecules are bound with only the toxic com­ ponent (41) .

Hence, modified relatives of botulinum toxin could be potent blockers of the release of norepinephrine, serotonin, neuropeptide, etc. Even if the lytic effect is of a generalized nature, such as inhibition of protein synthesis, the modified toxins could still be directed to poison only those nerves of a particular transmitter type. The obverse of these experiments might also prove highly fruitful. For example, the binding fragment could be used to direct a variety of pharmacologically active substances to, and into, cholinergic nerve endings.

Only the toxicity surviving after absorption differs depending upon the molecular struc­ ture of the toxin. REFERENCES 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. Jansen, B. C , Onderstepoort J. Vet. Res. 38, 93 (1971). Smith, L. , "Botulism—the organism, its toxins, the disease" Charles C. Thomas, Springfield, 111. (1977). , and Hottle, G. , J. Biol. Chem. 164, 63 (1946). Lamanna, C , MacElroy, Ο. , and Eklund, H. W. , Science 103, 613 (1946). Putnam, F. W. , Lamanna, C , and Sharp, D.

Download PDF sample

Rated 4.49 of 5 – based on 37 votes