Carbohydrate Modifications in Antisense Research (ACS by Yogesh S. Sanghvi, P. Dan Cook

By Yogesh S. Sanghvi, P. Dan Cook

Reports fresh advancements and growth within the carbohydrate-related chemistry of novel nucleic acid mimics and their functions in antisense therapeutics. Discusses using new chemical periods to rationally layout and synthesize oligonucleotides. Explores numerous carbohydrate changes of the oligonucleotide to stabilize opposed to nuclease degradation and to reinforce the binding affinity for a given aim. indicates destiny instructions of carbohydrate-related alterations for antisense molecules.

Show description

Read Online or Download Carbohydrate Modifications in Antisense Research (ACS Symposium Series) PDF

Similar botany books

Handbook to the Construction and Use of Insect Collection and Rearing Devices: A guide for teachers with suggested classroom applications

Bugs are nice lecture room learn organisms. they're effortless to assemble and lift and feature a desirable array of existence histories. simply because they're small and feature large reproductive potential ecological reviews of dispersion, predation, parasitism and replica may be studied in compressed timeframes and small parts relative to comparable experiences of bigger organisms.

Additional info for Carbohydrate Modifications in Antisense Research (ACS Symposium Series)

Example text

Barton, D. H. ; Géro, S. ; Samadi, M. Tetrahedron Lett. 1989, 30, 4969. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1994. ch002 38 CARBOHYDRATE MODIFICATIONS IN ANTISENSE RESEARCH 9. ;Orgel, L . E. Nucleosides Nucleotides 1990, 9, 771. 10. ; Gillessen, D. Tetrahedron Lett. 1989, 30, 1927. 11. Sinha, N . ; Köster, H . Nucl. Acids Res. 1984, 12, 4539. 12. Krecmerova, M . ; Hrebabecky, H . ; Holy, A . Collect. Czech. Chem. Commun. 1990, 55, 2521. 13. ; Wolf, R. M . ; Freier, S.

Xi) see vii, viii (Scheme 1). 4 4 2 2 2 2 2 3 3 2 2 2 DMTO, RO 65 RO Ret-BuPhjSi 68 NCCH CH O^Ô 2 2 N(»-Pr) 2 69 Scheme 14: i) H , Pd/C (10%), THF/MeOH (1:1). ii) Dess-Martin reagent, CII C1 . iii) TBAF, THF, AcOH. iv) see vii, viii) (Scheme 1). ; ACS Symposium Series; American Chemical Society: Washington, DC, 1994. 2. MESMAEKER ET AL. Novel Backbone Replacements for Oligonucleotides 35 We report here average values for the variation of the melting temperatures of the duplexes (T /modification) for the modifications 1-10 obtained from the duplexes A-D.

Ch003 2. 3. 4. 5. 6. 7. 8. 9. 10. A. Nucleic Acids Res. 1991, Symp. Ser. No. 24, 5-8. A. J. Org. 1992, 57, 2830-2835. A. J. Org. 1992, 57, 2983-2985. ; Chattopadhyaya, J. Tetrahedron 1993, 49, 2287-2298. K. Nucleic Acids Res. 1988, 16, 4583-4594. ; Feger, G. Nucleosides Nucleotides 1987, 6, 483-484. I. J. Org. Chem. 1993, 58, 7827-7831. A. Tet. Lett. 1993, 34, 5417-5420. D. Backbone Modified Oligonucleotide Analogs. International Patent W O 92/20, 823 (1992). M. Amides as Backbone Replacements in Oligonucleotides.

Download PDF sample

Rated 4.77 of 5 – based on 5 votes