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Extra info for Fortschritte der Arzneimittelforschung / Progress in Drug Research / Progrès des recherches pharmaceutiques
Basic Mechanisms of Drug Action 37 one asymmetric center, the more active compounds of each enantiomorphic pair were found to have the same configuration. The semi-rigidity of (- )-morphine and levorphan led BECKETT and CASY [92J to postulate that the important features of the analgesic receptor site are those shown in Figure 2. The features that are common to all analgesics with activity equal to or greater than that of meperidine include a basic group, which is almost completely ionized at physiological pH, and a flat aromatic ring.
If the channels are patent, the endoplasmic reticulum could be viewed as a sort of circulatory system within the cell. The significance of this in pharmacology is that it becomes possible to envisage the entry of quite large drug molecules into areas of the cell which were formerly regarded as the interior of the cell. These molecules might thus be brought into close proximity with the organelles of the cell while technically remaining outside. Of course, such molecules would still be separated from the organelles by a plasma membrane.
New York 1960), p. 103. [13J D. D. WOODS, Brit. J. Exp. Path. 21 (1940), 74. [14J A. , New York 1960), p. 50. [15J J. N. STANNARD, Am. J. Physiol. 126 (1939), 196. [16J K. C. FISHER, Can. Med. Assoc. J. 47 (1942). 414. [171 W. D. McELROY, Quart. Rev. BioI. 22 (1947), 25. [18J H. McILWAIN, Biochem. J. 49 (1951). 382. [19J H. McILWAIN, Biochem. J. 53 (1953), 403. [20J W. N. ALDRIDGE and V. H. PARKER, Biochem. J. 76 (1960),47. [21J F. E. SHIDEMAN and M. H. SEEVERS, J. Pharm. Expt. Therap. 74 (1942), 88.