Genetic and molecular aspects of sports performance by Bouchard C., Hoffman E. (eds.)

By Bouchard C., Hoffman E. (eds.)

This can be the most recent quantity within the IOC Encyclopaedia of activities drugs sequence, summarizing the facts from all appropriate resources at the genetic and molecular foundation of activities and different human actual performance.The preliminary chapters handle the fundamental technological know-how of genomics and genetics and the law of gene expression.  extra chapters supply authoritative details at the genetics of complicated functionality phenotypes, the contributions of small animal study, relatives and dual experiences, and ethnic comparisons.  a last part addresses the difficulty of the contribution of particular genes and molecular markers as on the topic of persistence, power and gear, and responsiveness to express conditioning programs. This most modern quantity within the Encyclopaedia of activities medication sequence from the scientific fee of the foreign Olympic Committee is a needs to for activities and workout scientists who require a radical advisor to the main leading edge technology during this increasing box.

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For the elite athlete, this accumulation of somatic mtDNA mutations eventually limits peak performance (Wallace & Lott, 2002). , 1992). , 2006). Somatic mtDNA point mutations also accumulate with age. , 1999). Furthermore, somatic point mutation levels are elevated in neurodegenerative diseases. , 2004). , 2006). , 2005). , 2008). Therapeutic Approaches to Enhance Mitochondrial Function Mitochondrial deficiencies might be treated by either metabolic or genetic therapies. Presumably, these same strategies could be used to enhance normal performance.

2007). Among elite Kenyan long-distance runners, haplogroup 22 c h a pter 2 L0 was strongly associated with endurance performance. , 2009). While a study of Ethiopian elite athletes did not reveal a strong association between mtDNA haplogroup and athletic performance, the Ethiopian samples lacked African haplogroup L0 mtDNAs. Assuming that the greatest difference in coupling efficiency occurred between haplogroup L0, the founding mtDNA haplogroup, and haplogroups L1, L2, and L3 which are similar to each other and less tightly coupled, then there might have been little functional differences between the Ethiopian mtDNA haplogroups.

Based on these results and similar trends observed in relation to various clinical problems, we can propose a preliminary hierarchy for mtDNA haplogroups: L0 Ͼ (L1, L2, L3) Ͼ I Ͼ H Ͼ U Ͼ J Ͼ Uk. For endurance longdistance runners, this list is arranged from high to low, while for sprinters the list is from low to high. Somatic mtDNA Mutations It is well established that athletic performance peaks in the latter teens and twenties, and then declines with age. This correlates with the accumulation of somatic mtDNA mutations in post-mitotic tissues with age.

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