By Rameshwar K. Sharma (auth.), Rameshwar K. Sharma (eds.)
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Extra resources for Guanylate Cyclase
Immunological and functional identity with 180 kDa membrane guanylate cyclase and ATP signaling site. FEBS Lett 296: 254-258, 1992 134. Schulz S, Green CK, Yuen PS, Garbers DL: Guanylyl cyclase is a heatstable enterotoxin receptor. Cell 63: 941-948, 1990 135. Singh S, Singh G, Heim JM, Gerzer R: Isolation and expression of a guanylate cyclase-coupled heat stable enterotoxin receptor cDNA from a human colonic cell line. Biochem Biophys Res Commun 179: 1455-1463,1991 136. de Sauvage FJ, Camerato TR, Goeddel DV: Primary structure and functional expression of the human receptor for Escherichia coli heatstable enterotoxin.
Science 245: 1392-1394, 1989 194. Marala RB, Sitaramayya A, Sharma RK: Dual regulation of atrial natriuretic factor-dependent guanylate cyclase activity by ATP. FEBS Lett 281: 73-76, 1991 195. Chinkers M, Singh S, Garbers DL: Adenine nucleotides are required for activation of rat atrial natriuretic peptide receptor/guanylyl cyclase expressed in a baculovirus system. J Bioi Chern 266: 4088-4093, 1991 196. Duda T, Goraczniak RM, Sitaramayya A, Sharma RK: Cloning and expression of an ATP-regulated human retina C-type natriuretic factor receptor guanylate cyclase.
Furthennore, high NP levels reflect increasedANP and BNP synthesis in ventricular myocytes observed during the development of cardiac hypertrophy . This elevation of plasma NP seems to be at odds with avid water and salt retention in patients with CHF and in experimental animals. Several groups have tried to detennine why salt and water retention is severe in CHF despite high levels of circulating NP. Furthennore, a blunted effect of exogenous ANP has been observed in CHF, suggesting either the hyporesponsiveness of target organs to ANP or activation of mechanisms opposing its actions.