Intrinsic Immunity by Eric W. Refsland, Reuben S. Harris (auth.), Bryan R. Cullen

By Eric W. Refsland, Reuben S. Harris (auth.), Bryan R. Cullen (eds.)

Recent examine has targeted recognition at the significance of intrinsic antiviral immunity, i.e. immunity mediated by way of elements which are constitutively expressed in lots of cells. during this quantity, top specialists offer a accomplished assessment of this fairly new and speedily evolving box. They hide intrinsic proteinaceous antiviral immune effectors, akin to the APOBEC3 and TRIM protein households in addition to Tetherin and SAMHD1, that have been before everything found through researchers learning HIV-1. moreover, the function of RNA interference in antiviral security in vegetation and invertebrates, in addition to the interaction among microRNAs and viruses in mammalian cells, are analysed. One bankruptcy discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors force either pathogen and host evolution, and at last the rising proof that DNA harm reaction proteins limit an infection by means of DNA viruses is highlighted.

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Fasicularis TRIMCyp bears the specificity enhancing R69H substitution in the CypA domain, which is expected to broaden restriction to HIV-2. However, M. fasicularis TRIMCyp also bears a second change, in this case E143K, that focuses specificity away from HIV-2 while maintaining restriction of HIV-1 and SIVtan (Ylinen et al.  2a).  2b). Note that R69H, which expands specificity, is present in all of the macaque TRIMCyps, whereas D66N, which narrows specificity toward HIV-2, is present in M. nemestrina (pigtail macaque) and M.

Interestingly, like Aotus TRIMCyp, the M. fasicularis (cynomolgus macaque) TRIMCyp restricts HIV-1, FIV, and SIVtan but not HIV-2 (Ylinen et al. 2010). M. fasicularis TRIMCyp bears the specificity enhancing R69H substitution in the CypA domain, which is expected to broaden restriction to HIV-2. However, M. fasicularis TRIMCyp also bears a second change, in this case E143K, that focuses specificity away from HIV-2 while maintaining restriction of HIV-1 and SIVtan (Ylinen et al.  2a).  2b). Note that R69H, which expands specificity, is present in all of the macaque TRIMCyps, whereas D66N, which narrows specificity toward HIV-2, is present in M.

J. Fletcher and G. J. 54 1 Introduction Tripartite motif-containing (TRIM) proteins are an ancient family of E3 ligases. They are characterized by a conserved architecture of two or three zinc-binding folds (one RING domain, one or two B-Box domains), a predicted coiled coil (collectively an RBCC), and usually a C-terminal domain that recruits specific interaction partners (Nisole et al. 2005). TRIM genes predate the emergence of metazoans (Marin 2012), appear sporadically in invertebrates (Sardiello et al.

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