Introduction to Biomolecular Energetics: Including by Irving M. Klotz

By Irving M. Klotz

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The hydrolysis of cytidine 2', 3'-cyclic phosphate has been studied widely, since this compound is a very convenient substrate for pancreatic ribonuclease. It would be desirable to know AG° for this hydrolysis. It is a relatively straightforward matter to * Selected Values of Chemical Thermodynamic Properties, Nat. Bur. Standards ( U . S . ) , Circ. 500, 1952; Technical N o t e 270-3, 1968; 270-4, 1969; 270-5, 1971; 270-6, 1971; 270-7, 1973; 270-8, 1981; J. O. Hutchens in "Handbook of Biochemistry," ( H .

At 1 atm and 25°C is 3. The equilibrium constants for the oxygenation reaction 0 2( g ) + H r ( a q ) ^ H r 0 2( a q ) , (4) where Hr represents hemerythrin (the oxygen-carrying pigment of Phascolopsis gouldii) are: 1 f(°C) /C(atm- ) 0 25 9120 380 (a) Using the thermodynamic relation d In Κ/dT = LH°/RT ΔΗ°, the heat of oxygenation. 5 kcal/mole. (b) Find A5°, the entropy change for reaction (4) at 25°C. 1 cal/mole deg. (c) Find AG° for the reaction: 0 2 (aq) + Hr (aq) = H r 0 2 (aq) 2 find (5) Answer: -7590 cal/mole.

Thus, one method of evaluating the stability of this bond is to determine the free energy of transfer AGt° of an apolar group from an organic environment to water. A number of such calculations have been made and lead to positive values of AGt° for apolar groups. Since hydrophobic bonds are of special interest in protein molecules, it would be particularly desirable to evaluate AGt° for apolar amino-acid side chains. However, these side chains cannot be plucked off by themselves. 34) that is, the free energy of transfer of the amino acid R - C H ( N H ^ ) C O O ~ is composed of two parts, that of the apolar R group, and that of the zwitterion base which may be approximated by glycine, H-CH(NHÎ)COO".

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