Mechanisms and Consequences of Proton Transport by Olga Vagin, Keith Munson, Jai Moo Shin, Nils Lambrecht,

By Olga Vagin, Keith Munson, Jai Moo Shin, Nils Lambrecht, Steve Karlish, George Sachs (auth.), Tetsuro Urushidani, John G. Forte, George Sachs (eds.)

This quantity represents the court cases of the ninth overseas Proton delivery convention, "Mechanisms and outcomes of Proton delivery" held in Leura, Australia, August 19 -21, two hundred I. This convention has been held considering 1971 each three to four years with few exceptions in organization with the Congress of the overseas Union of Physiological Sciences. the 1st assembly was once held in Frankfurt, Germany, on the Max-Planck'Institute. nations web hosting the convention were Germany (twice), Sweden (twice), India, Canada, united states, nice Britain, and now Australia. over the last 30 years individuals at those Proton shipping meetings were valuable individuals to the key discoveries within the body structure, biochemistry and pharmacology of gastric acid secretion. those contain improvement of the H2-receptor blockers, defining the signaling pathways for the legislation of acid secretion, picking out the gastric proton pump, discovery and improvement of proton pump inhibitory medicinal drugs, and elucidating the body structure and biochemistry of Helicobacter pylori.

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Mechanisms and Consequences of Proton Transport

This quantity represents the complaints of the ninth overseas Proton delivery convention, "Mechanisms and effects of Proton shipping" held in Leura, Australia, August 19 -21, 2 hundred I. This convention has been held on the grounds that 1971 each three to four years with few exceptions in organization with the Congress of the foreign Union of Physiological Sciences.

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RussianJ. Bioorgan. Chem. 23: 800-804, 1997. 29. Keeling, D. , Taylor, A. , and Schudt, C. The binding of a K+ competitive ligand, 2methyl,8-(phenylmethoxy)imidazo(l,2-a)pyridine 3-acetonitrile, to the gastric H,K-ATPase. J. Bioi. Chem. 264: 5545-5551,1989. 30. King, L. A. and Possee, R. D. The Baculovirus Expression System: A Laboratory Guide, London: Chapman & Hall, 1992, pp. 1-222. 30 Mechanisms and Consequences ofProton Transport 31. Kraut, J. , Shin, J. , and Scott, D. The Na,KATPase beta I subunit is associated with the HK alpha 2 protein in the rat kidney.

It was shown that the Atp1all-~HK complex is indeed a K+-dependent ATPase (Km - 375 11M). 7) is similar to that for Na,K- and gastric H,K-ATPases (26). This is consistent with the known ion-transport cycle of these enzymes, in which two potassium ions bind at the extracellular face of the enzyme. Most significantly, the Atplall-~HK-mediated inward K+ transport was inhibited by the Na,K-ATPase inhibitor, ouabain (Ki - 13 11M) and also by high concentrations of the gastric H,K-ATPase inhibitor, SCH28080 (-70% at 500 11M).

139-146, 2000. 37. , and Geering, K. Human ATP1ALl gene encodes a ouabain-sensitive H-K-ATPase. V(1995) Am. J. Physiol. 269: C992-C997, 1995. 38. Modyanov, N. , Petrukhin, K. , Sverdlov, V. , Orlova, M. , Kostina, M. , Makarevich, O. , Broude, N. , Monastyrskaya, G. , and Sverdlov, E. D. The family of human Na,K-ATPase genes. ATPIALl gene is transcriptionally competent and probably encodes the related ion transport ATPase. FEBS Lett. 278: 91-94, 1991. 39. , and Ie Maire, M. Structural organization, ion transport, and energy transduction ofP-type ATPases.

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