Metal Complex - DNA Interactions by Nick Hadjiliadis, Einar Sletten

By Nick Hadjiliadis, Einar Sletten

Steel ions and steel complexes have lengthy been well-known as severely vital elements of nucleic acid chemistry, either in rules of gene expression and as promising healing brokers. realizing how steel complexes have interaction with DNA has develop into an energetic study zone on the interface among chemistry, molecular biology and medication.

Metal complicated - DNA Interactions offers a entire assessment of this more and more assorted box, proposing fresh advancements and the most recent examine with specific emphasis on metal-based medications and steel ion toxicity. The textual content is split into 4 parts:

  • Basic Structural and Kinetic Aspects: contains chapters on sequence-selective steel binding to DNA and thermodynamic models. 
  • Medical Applications: specializes in anticancer platinum medicines, together with discussions on DNA fix in antitumor results of platinum medicinal drugs and photo-dynamic therapy.
  • DNA-Recognition - Nucleases and Sensor: describes probes for DNA acceptance, synthetic limit brokers, metallo-DNAzymes for steel sensing purposes and steel ion established catalysis in nucleic acid enzymes.
  • Toxicological Aspects: offers with structural experiences of mercury–DNA interactions, chromium-induced DNA harm and service, and the impression of arsenic and nickel on DNA integrity.

This e-book may be a helpful source for educational researchers and pros from a number of pharmaceutical and chemical industries, rather these all for the advance of recent and no more poisonous anticancer metallo-drugs, and within the box of environmental and toxicological chemistry.

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E. as relaxation probes producing broad lines or as paramagnetic shift probes producing narrow lines. Divalent manganese is a typical relaxation probe with an estimated electronic relaxation time (ts = T1c = Tc) of 10−8–10−9 s, while nickel, which has a shorter ts in the range 10−10–10−12 s, is a typical chemical shift probe. Cobalt(II) in a low-spin coordination environment has an estimated ts between that of Mn2+ and Ni2+ in kinetically labile metal complexes. At low metal to nucleotide ratios paramagnetic shift effects of Ni2+ are difficult to detect.

The adjacent residue (Y) on the 5′-side (5′-YGG) is found to exert a negligible influence on the selectivity. For the monofunctional binding of [PtCl(dien)]+ to double helical DNA the variation in reaction rates follows qualitatively the same selectivity pattern as for the labile metal ions. Experimentally observed relative rates of G-oxidation are found to match well with the NMR results. Nonselective equal G cleavage is observed for single-stranded DNA, in line with the NMR experimental data.

5′-CGCGTATACGCG 7. 5′-GCCGTGCACGGC 8. 5′-GCCGTTAACGGC 9. 5′-GCCTGATCAGGC 10. 5′-CCAAGCTTGG 11. 5′-GCCGAATTCGGC 12. 5′-ATGGGTACCCAT 13. 5′-TATGGTACCATA 14. 5′-TATGGATCCAAT 15. 5′-TATGGCCATA 16. 5′-GGCGCC Eco-RI Eco-RV AccI BglII HpaI BclI on the 3′-side according to the simple rule : 5′-GG ≥ 5′-GA > 5′-GT >> 5′-GC. Apparently, the residue on the 5′-side is less important. At higher metal ion concentrations most 1H NMR resonances undergo varying degrees of broadening. It must be stressed, however, that only relative broadening effects for each sequence are taken into account.

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