Microsurgical Models in Rats for Transplantation Research by Sun Lee (auth.), Prof. Dr. med. Arnulf Thiede, Dr. med.

By Sun Lee (auth.), Prof. Dr. med. Arnulf Thiede, Dr. med. Eberhard Deltz, Dr. med Rainer Engemann, Prof. Dr. med. Horst Hamelmann (eds.)

Preclinical experimental transplantation study that's in accordance with microsurgical types in rats fulfills integral stipulations for contemporary organ transplanta­ tion study: just about all organ grafts might be played at the rat with an volume of technical attempt that continues to be justifiable. hence transplantation types which are analogous to human organ transplantation could be built, established, and evaluated. This fulfills an important situation from the viewpoint of surgical procedure. With the species rat, we've got an excellent number of genetically diverse inbred traces. From the immunological viewpoint this can be an integral prerequisite for the research of preclinical transplantation versions that may be anticipated to provide controllable, reproducible effects. In vivo experimental effects could be supplemented through and correlated to in vitro exams. in recent times those experimental effects are being drastically increased and extra accurately outlined by means of the applying of immunohistological equipment which were proven lately in Kiel. during this publication we are hoping to give a pass element of the microsurgical types in use this day and of present immunological and immunohistological versions. in addition, we want to checklist the current nation of microsurgical organ transplantation learn and to teach its dating to the present kingdom and improvement of medical organ transplantation. a different element of our Kiel learn team is the long term, well-functioning, interdisciplinary cooperation among surgical procedure, immunology, and pathology. via this cooperation we try to supply an environment during which theoretical and sensible viewpoints can together impression each one other.

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The pulmonary veins were ligated and a left pneumonectomy was performed, leaving long arterial and bronchial stumps. The pulmonary artery anastomosis was then performed between three stay sutures in a running fashion with 9-0 Microvascular Pulmonary Transplantation in Rats 39 monofilament material. The bronchi were anastomosed end-to-end with a 7-0 continuous Prolene suture. The pulmonary artery was then clamped with a small bulldog clamp and the large clamp removed. The pericardium was entered dorsal to the phrenic nerve and the left atrial appendage clamped.

3 mm in diameter Possible Low Easy $ 30-$2000 High Moderate $ 2000- 30,000 Table 2. Advantages of inbred rat strains for transplantation research 1. Constant genetic difference within an experimental group 2. Syngeneic control groups for checking the transplantation technique 3. Defined variation of the genetic difference between experimental groups 4. Breeding of F 1-hybrid combinations for separating, analyzing, and manipulating isolated graft versus host and host versus graft Table 3. IN RTII RTlf RTla RTF RTlc RTl av1 RTl lv1 RTII RTlc RTIo F1 hybrids MHC (CAP x F344)F 1 (BNxLEW)F1 RTI cllv1 RT I 011 glasses, but very much more is needed for the operating microscope.

Transplantation 28:47-50 Limmer J, Caine RY (1981) A simplified technique for orthotopic liver transplantation in the rat using a cuff technique for portal vein and infrahepatic vena cava anastomoses. Eur Surg Res 13:236-242 Nitze (1897) Discussion remark. Zentralbl Chir 39: 1042 Nolan MS, Lindsey NJ, Savas CP (1982) Pancreatic transplantation in the rat. Transplantation 33:327-329 Ono K, Lindsey ES (1969) Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 57:225-229 Payr E (1900) Beitriige zur Technik der BlutgeHiB- und Nervennaht nebst Mitteilungen iiber die Verwendung eines resorbierbaren Metalles in der Chirurgie.

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