Molecular Mechanisms in Legionella Pathogenesis by Pedro Escoll, Monica Rolando (auth.), Hubert Hilbi (eds.)

By Pedro Escoll, Monica Rolando (auth.), Hubert Hilbi (eds.)

Legionnaires’ affliction, a most likely deadly kind of pneumonia essentially affecting aged and immuno-compromised folks, is because of the ever-present environmental bacterium Legionella pneumophila. This ebook deals authoritative experiences of other elements of its virulence, concentrating on comparative phagocyte an infection, virulence gene law, biochemical capabilities of effector proteins and mobile pathogen-host interactions, in addition to host responses and immunity to L. pneumophila. Taken jointly, the contributions during this compilation offer a cutting-edge evaluate of present insights into the molecular pathogenesis of the opportunistic and in all probability deadly pathogen L. pneumophila.

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2011). Besides these activities the amino-terminal domain of SidM/DrrA was shown to AMPylate Rab1, leading to its covalent modification. The AMPylation by SidM/DrrA limits the access of GTPase activating proteins (GAPs), thereby keeping Rab1 constitutively active (Muller et al. 2010; Murata et al. 2006). Interestingly, it was found that another effector- LegA9 Ceg14/SidL Ceg19 LegC5/Lgt3 LegAU13/AnkB LegA14 LepB Ceg32/SidI SidF VipA YlfB/LegC2 RalF YlfA/LegC7 LegA8/AnkX SidK lpg0402 lpg0437 lpg1121 lpg1488 lpg2144 lpg2452 lpg2490 lpg2504 lpg2584 lpg0390 lpg1884 lpg1950 lpg2298 lpg0634 lpg0695 lpg0968 b LqsR PmrA PmrA PmrA PmrA LetA LetA LetA LetA LqsR LqsA PmrA PmrA PmrA PmrA PmrA CpxR PmrA PmrA CpxR CpxR CpxR deAMPylates Rab1 Trafficking (yeast) Vacuole integrity, anti-apoptotic GEF and GDF for Rab1, AMPylates Rab1 Inhibition of vacuolar ATPase Preventing autophagy Inhibits eEF1A Trafficking (yeast) Glucosyltransferase of eEF1A AR/F-box Generates polyubiquitinated proteins on the LCV, supply amino acids for bacterial growth AR Trafficking (yeast) GAP for Rab1 Inhibits eEF1A Anti-apoptotic, phosphoinositide phosphatase Trafficking, binds actin Trafficking Sec7 GEF for ARF1 Trafficking Trafficking (yeast) AR Phsphocholinates Rab1 AR GRIP AR AR Heidtman et al.

Pneumophila to infect human macrophages evolved mainly during its evolution within free-living protozoa, but we cannot exclude that the interaction with other susceptible hosts, closer to higher eukaryotes than amoeba, has also shaped the Legionella-host interactions. The broad host range of L. pneumophila might be due to the many different effectors this bacterium has acquired during evolution probably during interaction with distant hosts, helping it now to infect even humans. In fact, L. pneumophila can colonize and persist within the digestive tract of the nematode Caenorhabditis elegans (Brassinga et al.

M. Rolando is holder of a Roux contract financed by the Institut Pasteur. References Abu Kwaik Y (1996) The phagosome containing Legionella pneumophila within the protozoan Hartmannella vermiformis is surrounded by the rough endoplasmic reticulum. Appl Environ Microbiol 62(6):2022–2028 Abu-Zant A, Jones S, Asare R, Suttles J, Price C, Graham J et al (2007) Anti-apoptotic signalling by the Dot/Icm secretion system of L. pneumophila. Cell Microbiol 9(1):246–264 From Amoeba to Macrophages 25 Akamine M, Higa F, Arakaki N, Kawakami K, Takeda K, Akira S et al (2005) Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila.

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