Non-Hodgkin Lymphoma: Prognostic Factors and Targets by Peter J. Quesenberry M.D., J. Reagan, B. Ramratnam, L.

By Peter J. Quesenberry M.D., J. Reagan, B. Ramratnam, L. Goldberg (auth.), Peter J. Quesenberry, Jorge J. Castillo (eds.)

This booklet could be the first that makes a speciality of exclusively on version organisms for lymphoma. it really is editors are the world over famous within the field.

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Extra resources for Non-Hodgkin Lymphoma: Prognostic Factors and Targets

Example text

Although this chapter dealt mainly with the pathogenesis of B-cell AIDS-related NHL, the literature addressing mechanisms underlying other HIV-related lymphomas such as Hodgkin lymphoma is emerging [15]. Elucidating the exact role of HIV lymphomagenesis will hopefully provide us with potential therapeutic targets in the near future. 42 L. Pantanowitz and A. Carbone References 1. Aboulafia DM, Pantanowitz L, Dezube BJ (2004) AIDS-related non-Hodgkin’s lymphoma: still a problem in the era of highly active antiretroviral therapy.

Carbone 41. Engels EA, Pittaluga S, Whitby D et al (2003) Immunoblastic lymphoma in persons with AIDS-associated Kaposi’s sarcoma: a role for Kaposi’s sarcoma-associated herpesvirus. Mod Pathol 16:424–429 42. Ferry JA (2006) Burkitt’s lymphoma: clinicopathologic features and differential diagnosis. Oncologist 11:375–383 43. Frisch M, Biggar RJ, Engels EA et al (2001) Association of cancer with AIDS-related immunosuppression in adults. JAMA 285:1736–1745 44. Engels EA, Goedert JJ (2005) Human immunodeficiency virus/acquired immunodeficiency syndrome and cancer: past, present, and future.

5 Anaplastic large T-cell lymphoma (ALCL) showing large atypical lymphoma cells infiltrating through cardiac muscle diagnosed at postmortem (H&E stain; high magnification) HIV-related immunosuppression [43], the exact relationship with CD4 count is unclear. In two large cohort studies, researchers found that there was a higher risk of Hodgkin lymphoma in HIV + persons treated with HAART compared to those who were not treated [24, 51]. Among these HAART-treated individuals, the relative risk compared with the general population appeared higher for Hodgkin lymphoma than for non-Hodgkin lymphoma.

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