By Anna Hoekstra, Gustavo C. Rodriguez (auth.), M. Sharon Stack, David A. Fishman (eds.)
Ovarian carcinoma remains to be liable for extra deaths than all different gynecologic malignancies mixed, as a result of a persevered lack of ability to accomplish detection of early (rather than complicated) level illness and the inability of potent tumor-specific therapeutics.
Ovarian carcinogenesis, invasion, and metastatic dissemination require a posh cascade of interrelated genetic, molecular, and biochemical occasions that control the neoplastic transition of standard ovarian floor epithelium.
This moment variation comprises fascinating new advances in ovarian melanoma detection and remedy and gives an research of present study into elements of malignant transformation, progress keep an eye on, and metastasis. A extra distinct realizing of those approaches may perhaps finally translate into the improvement of novel methods for the detection and regulate of ovarian cancer.
"Ovarian melanoma prevention, detection and remedy stay an important well-being care problem. during this textual content notion leaders within the box handle the severe biologic and scientific concerns suitable to the ailment. A entire spectrum of subject matters is roofed delivering modern info on medical discoveries and administration considerations."
Steven T. Rosen, M.D.
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Additional resources for Ovarian Cancer: Second Edition
Thus, mutations in the ras oncogene are rare in chicken ovarian cancers, similar to that in human ovarian cancers. 6%) demonstrated significant HER-2/neu staining, and significant expression of HER-2/neu was associated with the larger ovarian tumors, suggesting that it may be a marker of cancer aggressiveness in the chicken. 196,197 Clearly, the chicken, like any other animal model, is far removed from humans and thus suffers from this great limitation. Nonetheless, the clinical and genetic findings in the chicken model bear a resemblance to that in human ovarian carcinomas, thereby providing support for the chicken ovarian cancer animal model.
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