By Jean Cadet, Thierry Douki, Carine Badouard (auth.), Mark D. Evans B.Sc., Ph.D., Marcus S. Cooke B.Sc., M.Sc., Ph.D. (eds.)
This booklet presents an updated assurance of chosen themes within the zone of nucleic acid oxidation. the themes were chosen to hide every little thing from easy chemical mechanisms, fix of wear and tear and the organic and pathological which means of DNA oxidation. The chapters are authored by means of prime, study lively, foreign specialists within the respective subject matters. as well as a number of the typically lined issues, we now have integrated a few components that obtain much less awareness in comparable volumes, for instance chapters concentrating on harm to nucleic acids through halogenating and nitrating species, gene-specific harm, telomere shortening and harm to promoter areas. via this process, we realize also the significance of nucleic acid harm past mutation and in pathological stipulations except carcinogenesis. the first viewers for the ebook will be examine scientists and complex postgraduate scholars, the ebook can also be of curiosity to clinicians with robust study pursuits. we might anticipate readers to return clear of this ebook with a better appreciation of the subject, really appraising the reader of parts that won't unavoidably were lined in the sort of quantity before.
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47 32 Oxidative Damage to Nucleic Acids Summary and Conclusions Considerable advances have been made over the last few years in determining the kinetics and reactions ofchlorinating and nitrating species with isolated DNA and its components. It is now clear that a range ofdifferent oxidants can induce both direct and indirect modification of these materials, and that some of the products of these reactions can be used as quantitative markers ofDNA damage. The situation with intact cells and animals, is however, less clear-cut and considerable further work needs to be carried out to determine whether similar reactions and processes occur in vivo.
Kidney Int Suppl 1996; 55:S2-S5. 12. Ignarro LJ. Nitric oxide: A unique endogenous signalling molecule in vascular biology. Biosci Rep 1999; 19:51-71. 13. Darley Usmar V, Halliwell B. Blood radicals: Reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharm Res 1996; 13:649-662. 14. Patel RP, Levonen A, Crawford JH et al. Mechanisms of the pro- and anti-oxidant actions of nitric oxide in atherosclerosis. Cardiovasc Res 2000; 47:465-474. 15. Huie RE, Padmaja S.
We also discuss the merits and shortcomings of using these chlorinated and nitrated DNA products as potential biomarkers of disease. ' A number of other cell types, including vascular smooth muscle and endothelial cells, also express functional NAD(P)H oxidases. z Subsequent dismutation of this radical, either spontaneously or via the action ofsuperoxide dismutases, gives HzO z. f This enzyme catalyses the reaction of HzO z with physiological concentrations of Cl ions to give the potent oxidant HOCI (Fig.