Oxidative Damage to Nucleic Acids by Jean Cadet, Thierry Douki, Carine Badouard (auth.), Mark D.

By Jean Cadet, Thierry Douki, Carine Badouard (auth.), Mark D. Evans B.Sc., Ph.D., Marcus S. Cooke B.Sc., M.Sc., Ph.D. (eds.)

This booklet presents an updated assurance of chosen themes within the zone of nucleic acid oxidation. the themes were chosen to hide every little thing from easy chemical mechanisms, fix of wear and tear and the organic and pathological which means of DNA oxidation. The chapters are authored by means of prime, study lively, foreign specialists within the respective subject matters. as well as a number of the typically lined issues, we now have integrated a few components that obtain much less awareness in comparable volumes, for instance chapters concentrating on harm to nucleic acids through halogenating and nitrating species, gene-specific harm, telomere shortening and harm to promoter areas. via this process, we realize also the significance of nucleic acid harm past mutation and in pathological stipulations except carcinogenesis. the first viewers for the ebook will be examine scientists and complex postgraduate scholars, the ebook can also be of curiosity to clinicians with robust study pursuits. we might anticipate readers to return clear of this ebook with a better appreciation of the subject, really appraising the reader of parts that won't unavoidably were lined in the sort of quantity before.

Show description

Read Online or Download Oxidative Damage to Nucleic Acids PDF

Best nonfiction_9 books

Mechanisms and Consequences of Proton Transport

This quantity represents the complaints of the ninth overseas Proton shipping convention, "Mechanisms and effects of Proton shipping" held in Leura, Australia, August 19 -21, 2 hundred I. This convention has been held considering 1971 each three to four years with few exceptions in organization with the Congress of the foreign Union of Physiological Sciences.

Vertebrate Myogenesis

The improvement of vertebrate muscle has lengthy been a tremendous region of study in developmental biology. over the past decade, novel technical methods have allowed us to resolve to a wide quantity the mechanisms underlying muscle formation, and myogenesis has develop into one of many best-understood paradigms for mobile differentiation.

Crustacean Farming: Ranching and Culture, Second Edition

Crustacean Farming: Ranching and tradition, moment variation. John F. Wickins and Daniel O'C Lee. the second one version of a very well-received ebook, Crustacean Farming, offers with all cultivated crustaceans of industrial value, shrimp, prawns, crayfish, lobsters, crabs, and spiny lobsters, and examines the standards through which either the feasibility and desirability of farming proposals are assessed.

Merkel Cell Carcinoma

Merkel mobilephone Carcinoma is among the first complete, single-source medical texts at the topic. even though now not as universal as cancer, Merkel cellphone carcinoma isn't infrequent – and it's either extra lethal than cancer and extending at a pandemic fee. The booklet is scientific in concentration and emphasizes therapy of this poorly understood melanoma.

Additional resources for Oxidative Damage to Nucleic Acids

Example text

47 32 Oxidative Damage to Nucleic Acids Summary and Conclusions Considerable advances have been made over the last few years in determining the kinetics and reactions ofchlorinating and nitrating species with isolated DNA and its components. It is now clear that a range ofdifferent oxidants can induce both direct and indirect modification of these materials, and that some of the products of these reactions can be used as quantitative markers ofDNA damage. The situation with intact cells and animals, is however, less clear-cut and considerable further work needs to be carried out to determine whether similar reactions and processes occur in vivo.

Kidney Int Suppl 1996; 55:S2-S5. 12. Ignarro LJ. Nitric oxide: A unique endogenous signalling molecule in vascular biology. Biosci Rep 1999; 19:51-71. 13. Darley Usmar V, Halliwell B. Blood radicals: Reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharm Res 1996; 13:649-662. 14. Patel RP, Levonen A, Crawford JH et al. Mechanisms of the pro- and anti-oxidant actions of nitric oxide in atherosclerosis. Cardiovasc Res 2000; 47:465-474. 15. Huie RE, Padmaja S.

We also discuss the merits and shortcomings of using these chlorinated and nitrated DNA products as potential biomarkers of disease. ' A number of other cell types, including vascular smooth muscle and endothelial cells, also express functional NAD(P)H oxidases. z Subsequent dismutation of this radical, either spontaneously or via the action ofsuperoxide dismutases, gives HzO z. f This enzyme catalyses the reaction of HzO z with physiological concentrations of Cl ions to give the potent oxidant HOCI (Fig.

Download PDF sample

Rated 4.49 of 5 – based on 31 votes