Pharmacotherapy of Gastrointestinal Inflammation by Marco Romano, Antonio Cuomo (auth.), Antonio Guglietta

By Marco Romano, Antonio Cuomo (auth.), Antonio Guglietta (eds.)

In contemporary years, the world of pharmacotherapy of GI irritation has witnessed vital development, with new medicinal drugs and healing methods being brought. the quantity experiences the pharmacotherapy of chosen gastrointestinal inflammatory stipulations selected at the foundation in their scientific value and/or the parts the place vital and interesting development has been made lately. in addition to discussing present pharmacotherapy to regard crucial GI irritation stipulations, the publication additionally shows attainable destiny healing avenues more likely to turn into to be had in a number of years.
The e-book is of curiosity to numerous sectors of the clinical group starting from clinicians to pharmacologists and from biochemists to microbiologists, who will locate it a useful gizmo for his or her scientific perform and examine activity.

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Out of 282 patients 69% achieved fistula response to three-dose induction infliximab regimen at week 14. Through week 54, 5 mg/kg infliximab maintenance therapy every eight weeks was superior to three-dose induction followed by placebo maintenance. The median time to loss of fistula response was 14 weeks on placebo-maintenance; it was not achieved on infliximab maintenance (> 40 weeks). It was also superior in terms of complete fistula response for a longer period of time as well as in change in CDAI and IBD quality of life questionnaire.

Although there are several possible explanations for this lack of efficacy, one being that higher concentrations of ilodecakin appear to induce the expression of pro-inflammatory cytokines [119], clinical data do not support the use of this agent in CD [36, 120]. IL-11 Another cytokine, rhIL-11 (oprelvekin), has been launched for the prevention of severe thrombocytopenia following cancer chemotherapy. Since the anti-inflammatory properties of IL-11 (down regulation of macrophage function by inhibiting the expression on pro-inflammatory cytokines IL-1 and TNF-a) may be relevant for IBD, like its pro- 29 Marija Veljaca tective activity in rat model of colitis [121, 122], this cytokine was also explored as a potential treatment of CD.

ScandJ Gastroenterol31: 892-899 Langholz E, Munkholm P, Nielsen OH, Kreiner S, Binder V (1991) Incidence and prevalence of ulcerative colitis in Copenhagen county from 1962 to 1978. Scand J Gastroenterol26: 1247-1256 Munkholm P, Langholz E, Nielsen OH, Kreiner S, Binder V (1992) Incidence and prevalence of Crohn's disease in the county of Copenhagen, 1962-87: A sixfold increase in incidence. Scand J Gastroenterol27: 609-614 Loftus EV Jr, Silverstein MD, Sandborn WJ, Tremaine WJ, Harmsen WS, Zinsmeister AR (1998) Crohn's disease in Olmsted County, Minnesota, 1940-1993: incidence, prevalence and survival.

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