Polymorphism: In the Pharmaceutical Industry by Rolf Hilfiker

By Rolf Hilfiker

Edited by way of one of many best specialists within the box, this instruction manual emphasizes why solid-state concerns are very important, which methods will be taken to prevent difficulties and take advantage of the possibilities provided by way of good kingdom houses within the pharmaceutical and agricultural industries.
With its useful procedure, this can be straight away a suggestion for improvement chemists simply getting into the sector in addition to a solid resource of reference fabric for experts within the pharmaceutical and chemical undefined, structural chemists, physicochemists, crystallographers, inorganic chemists, and patent departments.

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At this stage, it is important that the formulation is quick and easy to produce, and other aspects such as shelf-life or ease of application play a minor role. Often, a tiered approach is used to test the drugs orally. Drug suspensions are the first choice [35], followed by pH-adjusted aqueous solutions, solutions in non-aqueous solvents and self-emulsifying lipid-based systems [41]. When using suspensions, it is very important to control particle size as this might have an effect on bioavailability.

Technol. Today, 1 (1998) 118–127. org). org). -G. in Handbook of Pharma- ceutical Salts: Properties, Selection, and Use (eds. Stahl, P. , Wermuth, C. ), Wiley-VCH, Weinheim (2002) pp. 221– 235. 19 21 2 Thermodynamics of Polymorphs Sachin Lohani and David J. W. 1 Introduction Polymorphism may be defined as the ability of a compound to crystallize in two or more crystalline phases with different arrangements and/or conformations of the molecules in the crystal lattice [1]. Hence, polymorphs are different crystalline forms of the same pure chemical compound.

Primary nucleation can be further classified into homogeneous nucleation, which occurs spontaneously in bulk solutions, and heterogeneous nucleation, which occurs at interfaces or surfaces and may be induced by foreign particles. Homogeneous nucleation is practically feasible only in a small volume of solution by the microdroplet levitation technique [52, 53] and is generally not observed in solutions of volume greater than 100 lL. In practice, heterogeneous nucleation and/ or secondary nucleation are commonly encountered.

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