Proceedings of the Research Symposium on Complexes of by Fred E. Hahn (auth.), Fred E. Hahn (eds.)

By Fred E. Hahn (auth.), Fred E. Hahn (eds.)

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Additional info for Proceedings of the Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action: Held at the Walter Reed Army Institute of Research Washington, 16–19 March 1970

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Thus poly d(G-C)· poly d(G-C), poly d(T-G) . poly d(C-A) and poly d(T-T-G) . poly d(C-A-A) bind more AM and bind AM more tightly than do poly dG·poly dC, poly d(T-C)·poly d(G-A) and poly d(T-T-C) . poly d(G-A-A), respectively. Such a comparison is not possible with poly dA ·poly dT, poly d(A-T)· poly d(A- T), poly dI· poly dC and poly d(I-C) . poly d(I-C) since none of these polymers binds AM. A variety of physical and enzymatic data indicates that the poly d pur· poly d pyr isomer is somewhat anomalous when compared to the poly d(purn-pyrm) .

BioI. 51,551 (1970). , BATCHO, A. : (1) J. Amer. chern. Soc. 87, 5793 (1965). : (2) J. Amer. chern. Soc. 87, 5791 (1965). - BATCHO, A. , CZAJKOWSKI, R. : J. Amer. chern. Soc. 90, 5641 (1968). , CROTHERS, D. : J. molec. BioI. 35, 251 (1968). : Biochem. Pharmacol. 17, 315 (1968). TENDLER, M. ) 199, 501 (1963). Inhibition of RNA Synthesis by Quinone Antibiotics WALTER KERSTEN I. Introduction During the last decade, a considerable number of drugs, many of them antibiotics, have been shown to interfere with the replication of DNA or the information transfer from gene to protein at the transcriptional level.

Chemical study of antitumor antibiotic sibiromycin. Antibiotiki 15, 297 (1970). DUDNIK, Ju. : Induction of lysogenic Micrococcul /ylodeikticul by antibiotics with the ability to affect DNA synthesis. Antibiotiki 10, 112 (1965). GAUSE, G. , PREOBRAZHENSKAYA, T. , IVANITSKAYA, L. , SVESHNIKOVA, M. : Production of antibiotic sibiromycin by Streptolporangium sibiricum. Antibiotiki 14, 963 (1969). : Anthramycin, a new type of DNA-inhibiting antibiotic. Biochim. biophys. ) 155, 121 (1968). KONSTANTINOVA, N.

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