Progress in Drug Research / Fortschritte der by Dr. B. Berde, Prof. Dr. C. J. Cavallito, Dr. I. M.

By Dr. B. Berde, Prof. Dr. C. J. Cavallito, Dr. I. M. Hunneyball, Dr. Satyavan Sharma, Dr. S. K. Dubey, Dr. R. N. Iyer, Prof. Dr. J. R. Smythies, Dr. D. Wray (auth.), Ernst Jucker (eds.)

Volume 24 contains six contributions, the writer and paper index of volumes 1-24 and the keyword index. because quantity 23 integrated an index for volumes 16-23 the reader has the chance to exploit those monographs as an encyclopedia and is within the place to discover references to nearly all fields of drug learn. The editor hopes that the articles of the current quantity will turn out fascinating and worthwhile to many scientists and will be thankful to obtain feedback and critiques from readers, as long ago case over the twenty years during which this sequence of monographs has existed. during this appreciate, thank you are because of all colleagues who've supplied valuable feedback of previous volumes, thereby assisting the editor in his paintings. Dr. A. Naf back has assisted the editor and has conscientiously reviewed all manuscripts, formulae and references, and has corrected the proofs. thank you are because of him for this tremendous paintings. even as, the editor want to thank the publishers and printers, Verlag Birkhliu­ ser, particularly Messrs. Th. Birkhliuser and C. Einsele, for the wonderful cooperation and the paintings they've got accomplished.

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169]. At higher concentrations, the time constant of miniature end-plate currents is prolonged by these agents, while the amplitude is decreased. c. decays were found [163, 164, 170]. The overall effect for these agents at higher concentrations is still a reduction in amplitude of (miniature) end-plate potentials. The effect of halothane, chloroform and enflurane on the channel properties remains to be clarified by noise analysis. ). Corresponding with these changes in chan8) End-plate currents in the presence of hexanol are biphasic [171].

Smythies: Structure and function of convulsant drugs I 59 Introduction In 1974, I published [I] an analysis of the structure-activity relationships of convulsant drugs in terms of their relationships to model receptors for GABA and glycine. However, this early model did not distinguish between drugs acting at the amino acid receptors and those acting at the ionophores these receptors controL This present analysis therefore seeks to add this extra dimension. My method is to examine a wide range of compounds acting at a particular site in terms of their molecular structure as revealed by CPK models, and then to attempt to deduce the simplest protein structure that is complementary to all these drugs, agonists as well as antagonists.

Appendix. . . . . . . . . . . . . . . . . . . . . .. References .......................................... 59 59 60 62 62 62 63 63 63 63 65 65 66 66 66 67 68 68 68 69 70 70 71 71 71 73 74 74 74 75 75 76 76 80 81 58 J. R. p. Hexahydro-2' -methylspiro[ cyclohexane1,8'(6H)-oxazine(3,4-A )pyrazine1 eq. 2 of secondary (upper = U) chain - and so on 1757IS 5, 7-Diphenyl-l ,3-diazadamantan-6-ol N(:) Nitrogen (with spare electron pair) 0(:) Oxygen (with spare electron pair) OH Hydroxyl group J.

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